Brand name: Incivek and Incivo Developed by: Vertex Pharmaceuticals and Johnson & Johnson Therop-Cat: anti-viral (protease inhibitors) Indication: hepatitis C Chemical name: (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide CAS#402957-28-2 Chemical structure: Intermediates of Telaprevir: 1. CAS#87269-87-2:(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride 2. CAS#1147103-42-1: (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid […]
DetailsAuthor Archives: Reliablepharmatech
Brexpiprazole
Trade name: Rexulti Originator: Otsuka and Lundbeck Therop-Cat: atypical antipsychotic Indication: schizophrenia, depression Chemical name: 7-[4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy]quinolin-2(1H)-one CAS# 913611-97-9 Chemical structure: Intermediates of Brexpiprazole: CAS# 203395-59-9 : 7-(4-bromobutoxy)quinolin-2(1H)-one 2. CAS# 913613-82-8: 7-(4-chlorobutoxy)-2(1H)-quinolinone 3. CAS# 5118-13-8: 4-bromo-benzo[b]thiophene 4. CAS# 913614-18-3: Piperazine, […]
Details
Ivabradine
Trade name: Corlanor (USA) Originator: Amgen and Servier Therop-Cat: cardiovascular Indication: heart-related chest pain and heart failure Chemical name: 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one CAS#155974-00-8 Chemical structure: During its development, ivabradine was known as S-16257. Intermediates of Ivabradine: 1. 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Cas […]
Details
Alogliptin
Trade name: Nesina, Vipidia Originator: Takeda Therap-Cat: Anti-diabetic Indication：Type 2 diabetes Chemical name：2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile CAS#: 850649-62-6 Chemical structure: Intermediates of Alogliptin: 4318-56-3 849217-48-7 188111-79-7 334618-23-4 865758-96-9 22115-41-9 Add: 7-3-601, Zuoanmingdi, Xianshuigu,Jinnan District, Tianjin 300350 ChinaTel&Fax: +86-22-28567687Mobile: +86-15620196887Email: sales@reliablepharmatech.com
Details
Afatinib
Trade name： Giotrif Therap-Cat: Anticancer Originator: Boehringer Ingelheim Indication：the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC) Chemical name：N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide CAS#: 850140-72-6 Chemical structure: Intermediates of Afatinib: 162012-67-1 86087‐23‐2 314771-76-1 […]
Details
Sitagliptin
Sitagliptin Trade name： Januvia Therap-Cat: Antidiabetic Originator: Merck & Co. Indication：diabetes mellitus type 2 First approved by USFDA in 2006 Chemical name：(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine CAS#: 486460-32-6 Chemical structure: Intermediates of Sitagliptin: CAS# 486460-00-8 Chemical name: (3R)-3-(1,1-dimethylethoxy carbonyl)amino-4-(2,4,5-trifluorophenyl)butanoic acid Chemical structure: […]
DetailsJuly 2017 CFDA Approves Valsartan/Sacubitril (Entresto) Combination for Heart Failure
The combination drug, formerly known as LCZ696, is the first approved agent in the angiotensin receptor-neprilysin inhibitor (ARNI) class and exerts its effect within and beyond the renin-angiotensin system. Chemically, the agent consists of the angiotensin-receptor […]
Details
Sacubitril
Trade name: EntrestoSponsor: NOVARTISTherop-Cat: heart failureIndication: reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.Chemical name of Sacubitril:4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acidCAS#149709-62-6Chemical structure:Intermediates of […]
Details
Aplysiatoxin/Dolastoxin
Therop-Cat: Cytotoxic linear peptide Indication: anti-cancer CAS#: 52659-57-1 Chemical structure: Intermediates of Aplysiatoxin/Dolastoxin:CAS#37577-28-9 : (1S,2R)-(+)-2-AMINO-1-PHENYL-1-PROPANOLChemical structure:2. CAS#120205-48-3 : 2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino) heptanoate hydrochloride (1:1)Chemical structure:3. CAS#120205-50-7 : ((2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-Methoxy-2-Methylpropanoic acidChemical structure: Add: 7-3-601, Zuoanmingdi, Xianshuigu,Jinnan District, Tianjin 300350 ChinaTel&Fax: […]
Details
Tedizolid Phosphate
Tedizolid Phosphate（formerly torezolid）Trade name: SivextroSponsor: CUBIST PHARMACEUTICALSTherop-Cat: an oxazolidinone-class antibioticIndication: acute bacterial skin and skin structure infections (ABSSSI)Chemical name: [(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphateCAS# 856867-55-5Chemical structure: TedizolidCAS#856866-72-3Chemical name: (R)-3-(3-fluoro-4-(6-(2-Methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxyMethyl)oxazolidin-2-oneChemical structure: Intermediates of TedizolidCAS#444335-16-4 : (5R)-3-(4-broMo-3-fluorophenyl)-5-(hydroxyMethyl)-1,3-oxazolidin-2-oneChemical structure: 2. CAS#1056039-83-8 : 2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridineChemical […]
Details