Trade name: Entresto

Sponsor: NOVARTIS

Therop-Cat: heart failure

Indication: reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.

Chemical name of Sacubitril:

4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid

CAS#149709-62-6

Chemical structure:

Intermediates of sacubitril:

CAS#1012341-50-2 : (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

Chemical structure:

CAS#1012341-48-8: (2E,4R)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid

Chemical structure:

CAS#149690-12-0: (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride

Chemical structure: 

CAS#1426129-50-1:  (R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate

Chemical structure:

CAS#1038924-61-6: (S)-5-(Biphenyl-4-yl)methyl pyrrolidin-2-one

Chemical structure: