Sitagliptin

Trade name： Januvia

Therap-Cat: Antidiabetic

Originator:  Merck & Co.

Indication：diabetes mellitus type 2

First approved by USFDA in 2006

Chemical name：(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

CAS#: 486460-32-6

Chemical structure:

Intermediates of Sitagliptin:

1. CAS# 486460-00-8
   Chemical name: (3R)-3-(1,1-dimethylethoxy carbonyl)amino-4-(2,4,5-trifluorophenyl)butanoic acid
   Chemical structure:
   
2. CAS# 209995-38-0
   Chemical name: 2,4,5-trifluorophenylacetic acid
   Chemical structure:
   
3. CAS# 486460-21-3
   Chemical name: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine
   Chemical structure:
   
4. CAS# 762240-92-6
   Chemical name: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine Hydrochloride
   Chemical structure:
   
5. CAS# 6485-52-5
   Chemical name: (S)-phenylglycinamide
   Chemical structure: