Trade name: Corlanor (USA) Originator: Amgen and Servier Therop-Cat: cardiovascular Indication: heart-related chest pain and heart failure Chemical name: 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one CAS#155974-00-8 Chemical structure: During its development, ivabradine was known as S-16257. Intermediates of Ivabradine: 1. 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Cas […]
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July 2017 CFDA Approves Valsartan/Sacubitril (Entresto) Combination for Heart Failure
The combination drug, formerly known as LCZ696, is the first approved agent in the angiotensin receptor-neprilysin inhibitor (ARNI) class and exerts its effect within and beyond the renin-angiotensin system. Chemically, the agent consists of the angiotensin-receptor […]
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Trade name: EntrestoSponsor: NOVARTISTherop-Cat: heart failureIndication: reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.Chemical name of Sacubitril:4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acidCAS#149709-62-6Chemical structure:Intermediates of […]
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